The Bombay Blood Group is rare blood group with absence or deficiency of H antigen. This is first reported in Bombay (Mumbai) 1952. Named for the city in which it was first discovered. It is a blood group which shows absence of A, B, H antigens on red cells and presence of anti-A, anti-B and anti-H antibodies in serum. The H antigen is located on the surface of red blood cells and is the precursor of A and B antigens. H antigen can be synthesized by H gene FUT1 and FUT2 which is located on chromosome 19 and give rise to glycosyl transferase that add 1-fucose to a precursor substance to produce H antigen on red cells. Bombay group would be categorized as O group because they wouldn’t show any reaction to anti-A and anti-B antibodies just like a normal O group. When a cross matching is done then it would show cross-reactivity or incompatibility. The reverser or serum grouping has to be performed to detect the Bombay blood group.
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